Approvals of COVID-19 vaccines by regulatory authorities have given hope that an end to the acute phase of the pandemic is within reach. To realize the full potential of these vaccines, they must be distributed in an equitable manner that prioritizes health care workers, front line responders (including Red Cross and Red Crescent staff and volunteers) and other high-risk groups. Building trust, reaching the most vulnerable and engaging communities in a two-way dialogue to ensure they have accurate information and relevant tools to protect themselves are essential elements in the Red Cross and Red Crescent’s contribution to ending the COVID-19 pandemic.