With the introduction of the Asia Pacific MHPSS Training and Learning Collaborative, the efforts towards strengthening MHPSS in the region have grown, through collaborations with partner National Societies to improve the quality of services and support the implementation of Psychological First Aid (PFA) for All. To help illustrate the efforts done in the region, we are presenting four case studies in this publication to highlight the various approaches done to address MHPSS needs in times of a global pandemic, along with insights from a survey conducted on the concept of pandemic fatigue.